Protein name:
Dual oxidase 1 ;
Alternative:
NADPH thyroid oxidase 1 (Thyroid oxidase 1) ;
Organism:
Dog (Canis familiarisCanis lupus familiaris).
General Annotation
Sub Unit:
Interacts with TPO and CYBA (By similarity). Interacts with TXNDC11.
Function:
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Subcellular Location:
Apical cell membrane
Multi-pass membrane protein
Localizes to the apical membrane of epithelial cells.
Protein Attributes:
50:
MGFCLALTWT | FLVGSWTSMG | AQKPISWEVQ | RFDGWYNNLM | EHKWGSKGSR |
100:
LQRLVPASYA | DGVYQPLGEP | HLPNPRDLSN | AAMRGPAGQA | SLRNRTVLGV |
150:
FFGYHVLSDL | VSVETPGCPA | EFLNIRIPPG | DPVFDPNGRG | DVVLPFQRSR |
200:
WDPESGQSPS | NPRDLTNAVT | GWLDGSAIYG | SSHSWSDALR | SFSGGQLASG |
250:
PDPAFPRNAQ | PPLLMWSAPD | PASGQRGPGG | LYAFGAERGN | RDPFLQALGL |
300:
LWFRYHNLCA | QRLARQHPHW | GDEELFQHAR | KRVIATYQNI | ALYEWLPSFL |
350:
QQAPVKYAGY | NPFLDPSISP | EFLVASEQFF | STMVPPGIYM | RNASCHFQEV |
400:
INRNSSISRA | LRVCNSYWSR | KHPNLRRAED | VDALLLGMAS | QIAEREDHVV |
450:
VEDVLDFWPG | SLKFSRTDHV | AGCLQRGRDL | GLPSYTKARA | ALGLPPITRW |
500:
QDINPALSQN | NHTVLEATAA | LYNQDLSQLE | LLPGGLLESH | GDPGPLFSAI |
550:
VLNQFVRLRD | GDRYWFENTR | NGLFSEEEIA | EIRNTSLRDV | LVAVTNMNPS |
600:
TLQPNVFFWH | MGDPCPQPRQ | LSTQGLPACA | PSTMQDYFEG | SGFGFGVTIG |
650:
TLCCFPLVSL | LSAWIVARLR | KKNFKKLQGQ | DRKSVMSEKL | VGGMEALEWQ |
700:
GHKEPCRPVL | VHLQPGQICV | VDGRLSVLRT | IQLRPPQQVN | LILSGNRGRR |
750:
ALLLKIPKEY | DLVLLFNLEE | ERQVLVENLR | GALKESGLKF | QEWELREQEL |
800:
MRTAVTRQQR | SHLLETFFRH | LFSQVLDIDQ | ADAGTLPLDS | SQKVQEALTC |
850:
ELSRAEFAES | LGLKPQDMFV | ESMFSLADKD | GNGYLSFREF | LDILVVFMKG |
900:
SPEEKSRLMF | RMYDFDGNGL | ISKDEFIRML | RSFIEISNNC | LSKAQLTEVV |
950:
ESMFRESGFQ | DKEELTWEDF | HFMLRDHDSE | LRFTQLCVRG | VEVPEVIKDL |
1000:
CRRASYISQE | KICPSPRVSA | RCPHSNTEVE | WTPQRLQCPV | DTDPPQEIRR |
1050:
RFGKKVTSFQ | PLLFTEAQRE | KFQRSRRHQT | LQQFKRFIEN | YRRHIGCVAV |
1100:
FYAITGGLFL | ERAYYYAFGA | HHMGITDTTR | VGIILSRGTA | ASISFMFSYI |
1150:
LLTMCRNLIT | FLRETFLNRY | VPFDAAVDFH | RLIASTAIVL | TVLHSAGHVV |
1200:
NVYLFSISPL | SVLSCLFPGL | FHNDGSEFPQ | KYYWWFFQTV | PGLTGVMLLL |
1250:
VLAIMYVFAS | HHFRRHSFRG | FWLTHHLYIL | LYVLLIIHGS | FGLIQLPRFH |
1300:
IFFLVPALIY | VGDKLVSLSR | KKVEISVVKA | ELLPSGVTHL | QFQRPQGFEY |
1350:
KSGQWVQIAC | LALGTTEYHP | FTLTSAPHED | TLSLHIRAAG | PWTTRLREIY |
1400:
SPPTGDGCAK | YPKLYLDGPF | GEGHQEWHKF | EVSVLVGGGI | GVTPFASILK |
1450:
DLVFKSSVSC | QVFCKKIYFI | WVTRTQRQFE | WLADIIREVE | ENDCQDLVSV |
1500:
HIYITQLAEK | FDLRTTMLYI | CERHFQKVLN | RSLFTGLRSI | THFGRPPFEP |
1550:
FFKSLQEVHP | QVRKIGVFSC | GPPGMTKNVE | KACQLINRQD | RTHFSHHYEN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Dog
Pig
ELISA Kit for Dog Dual oxidase 1
ELISA Kit for Dog Dual oxidase 1
ELISA Kit for Dog Dual oxidase 1
ELISA Kit for Dog Dual oxidase 1
CLIA Kit for Dog Dual oxidase 1
CLIA Kit for Dog Dual oxidase 1
CLIA Kit for Dog Dual oxidase 1
CLIA Kit for Dog Dual oxidase 1
Polyclonal Antibody for Dog Dual oxidase 1
Polyclonal Antibody for Dog Dual oxidase 1
Polyclonal Antibody for Dog Dual oxidase 1
Polyclonal Antibody for Dog Dual oxidase 1
Monoclonal Antibody for Dog Dual oxidase 1
Monoclonal Antibody for Dog Dual oxidase 1
Monoclonal Antibody for Dog Dual oxidase 1
Monoclonal Antibody for Dog Dual oxidase 1
Protein for Dog Dual oxidase 1
Protein for Dog Dual oxidase 1
Protein for Dog Dual oxidase 1
Protein for Dog Dual oxidase 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INDUCTION
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;CATALYTIC ACTIVITY;ENZYME REGULATION;GLYCOSYLATION
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TXNDC11